Calcineurin inhibitors suppress the high-temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: a new method of screening for calcineurin inhibitors
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منابع مشابه
Calcineurin inhibitors suppress intestinal cellular respiration
The calcineurin inhibitors, tacrolimus and cyclosporine, are commonly used immunosuppressants, and transplant patients on these medications often develop gastrointestinal symptoms. This in vitro study investigated their effects on intestinal cellular respiration (the process of delivering nutrients and O2 to the mitochondria, oxidation of reduced metabolic fuels, passage of electrons to O2, and...
متن کاملThe SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin.
The highly conserved RCN family of proteins regulates the serine/threonine protein phosphatase calcineurin, which is required for the expression of genes involved in Ca(2+)-dependent processes, such as the control of memory, apoptosis, T cell activation, cell cycle, Ca(2+)-homeostasis, and skeletal and cardiac muscle growth and differentiation. However, RCNs regulate calcineurin through two par...
متن کاملHow calcineurin inhibitors cause hypertension.
Calcineurin is a calcium-dependent serine–threonine protein phosphatase. Calcineurin activates the nuclear factor of activated T-cells cytoplasmic (NFAT)c, a transcription factor, by dephosphorylating the protein. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T-...
متن کاملCalcineurin inhibitors in chronic urticaria.
PURPOSE OF REVIEW The purpose of the review is to review the pathophysiology, available data, and our current recommendations for calcineurin inhibitor (cyclosporine and tacrolimus) treatment in antihistamine refractory chronic idiopathic urticaria (CIU) patients. RECENT FINDINGS Low-dose cyclosporine (<5 mg/kg per day) may have unique immunological modulating properties beyond mast cell and...
متن کاملCalcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney
Calcineurin is a serine/threonine phosphatase originally involved in the immune response but is also known for its role as a central mediator in various non-immunological intracellular signals. The nuclear factor of activated T cell (NFAT) proteins are the most widely described substrates of calcineurin, but ongoing work has uncovered other substrates among which are the cytoskeleton organizing...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2014
ISSN: 1567-1356
DOI: 10.1111/1567-1364.12143